Background: Presence of isolated anti-HBc antibody is common in HIV-infected patients in endemic areas and could\nbe caused by prior HBV infection with loss of anti-HBs antibody. The role of vaccination in these patients remains\ncontroversial and is based largely on limited and low quality data. We, therefore, conducted this study to determine\nimmunogenicity and safety of 4 vs. 3 standard doses of HBV vaccination in HIV-infected adults with isolated anti-HBc\nantibody.\nMethods: An open-label, randomized controlled trial was conducted among HIV-infected patients visiting HIV clinic\nof the Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand between July and September 2017..................
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